What is the Best way to test a compressed MSI that is within a setup.exe

Most our installs have the MSI exposed for install, but we do have 1 click installs, as well as compressed within the setup.exe

In Finalbuilder  6 I am trying to establish a testing process for all cases mentioned above.

Most of the time I am finding using the Executable that is included with the MSI is a better solution, simply it is comon with all packages.  It also has more functionality to detect on upgrades when executed.